Proteomics and metabolomics are two important fields of study in systems biology that play crucial roles in drug discovery. They provide comprehensive insights into the molecular mechanisms of diseases and the effects of drugs, enabling the identification of new therapeutic targets and biomarkers.
Proteomics in Drug Discovery
Proteomics is the large-scale study of proteins, their structures, functions, and interactions. It involves the systematic analysis of the entire protein complement (proteome) of a cell, tissue, or organism.
Role in Drug Discovery:
Metabolomics in Drug Discovery
Metabolomics is the comprehensive study of metabolites, the small molecule intermediates and products of metabolism within a biological system. It aims to measure and analyze the dynamic changes in the metabolome under different physiological conditions.
Role in Drug Discovery:
Drug Mechanism of Action:
Metabolomic studies can reveal how drugs alter metabolic pathways, providing a better understanding of their mechanisms of action and potential off-target effects.
Integration of Proteomics and Metabolomics
The integration of proteomics and metabolomics provides a holistic view of the molecular changes occurring in response to disease and drug treatment. This systems biology approach allows for:
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