Small molecule drug design involves the development of therapeutic compounds that are relatively small in size and molecular weight, typically less than 900 Daltons. These molecules are designed to interact with specific targets in the body, such as proteins, enzymes, or receptors, to modulate biological processes and treat diseases. Small molecule drugs represent a significant portion of the pharmaceutical market and are widely used to treat a variety of conditions. Here's an overview of small molecule drug design:
Steps in Small Molecule Drug Design
Clinical Development:
Drug candidates that successfully complete preclinical testing progress to clinical trials, which consist of three phases:
Advantages of Small Molecule Drugs
Challenges and Limitations
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